The microlattice is synthesized by means of solid phase activation through light activation with pre-made masking plate and modified 4 bases. Prior to synthesis, the slide is aminotized and the activated amino group is protected by a photounstable protectant. One end of a monomer molecule is activated and the other end is protected by a photosensitive protective agent. Select the appropriate light baffle to make the parts that need to be polymerized transparent, and the sites that do not need to be polymerized are masked. In this way, the light shines on the support material through the light baffle, and is protected by the amino hydrolysis of the light part, so that the coupling reaction with the monomer molecule occurs.
Each reaction adds a specific base to thousands of sites. Since the site of the reaction is still protected by the protective agent, it is possible to synthesize a large number of predetermined sequences of oligonucleotides or oligopeptides at a specific site by controlling the light transmission and shading patterns of the light shield and the types of monomer molecules involved in the reaction each time.