The B460 motherboard can support the 10th generation of Intel Core processors, including the i3 10100, i5 10400, i5 10500, i7 10700 and other cpus. Therefore, the B460 motherboard can replace the B250 motherboard. However, if your computer uses an AMD Ryzen processor, you will need a motherboard that uses the AM4 interface.
The b460 can replace the b250. The b46o picture is larger and clearer than the b250.