The Asus B250M-PLUS is a motherboard based on the Intel B250 chipset. The chipset itself does not support memory frequencies above 2400MHz (DDR4). However, some motherboard manufacturers can make B250 chipset motherboards support higher memory frequencies through overclocking or other optimization techniques.
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In the case of the Asus B250M-PLUS, although it supports memory frequencies up to 2666MHz, it is not guaranteed to operate reliably in all situations. Using high frequency memory may require some setup in the BIOS and may require some fine-tuning for optimal performance. Also, different brands and models of memory may have different compatibility, so it may be necessary to try different memory to find the right combination.
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In summary, the Asus B250M-PLUS can theoretically support a memory frequency of 2666MHz, but it may encounter some challenges in practice. Before upgrading the memory module, ensure that the memory module is compatible with the mainboard and perform proper Settings in the BIOS.