The answer is as follows: BGI Sequencers are mainly based on high-throughput sequencing technology. The idea is to break a DNA sample into several smaller DNA fragments, and then sequence it on a DNA chip with a fixed sequence.
DNA chips contain thousands of fixed sequences, and each sequence corresponds to the sequencing reaction of a DNA fragment.
In the sequencing reaction, DNA fragments are added to the reaction tube one by one, and reagents such as DNA polymerase, primer, and four different fluorescently labeled nucleotides are added.
The fluorescently labeled nucleotides are added to the DNA strand by DNA polymerase, releasing a fluorescent signal.
By detecting the intensity and color of the fluorescence signal, the sequence of each DNA fragment can be determined.
Eventually, the computer will stitch together the sequence of all the fragments to get the sequence of the entire DNA sample.