Piezoelectric biochip is a kind of biochip, which converts the change of crystal surface quality after reaction into the transformation of crystal vibration frequency, and can continuously monitor the reaction in real time by recording the frequency change, so as to achieve the purpose of qualitative and quantitative detection. At present, the application fields of biochip technology mainly include gene sequencing and analysis, new gene discovery, gene analysis, disease diagnosis and prediction, and drug screening. In addition, biochips will play an important role in agriculture, food supervision, environmental protection, judicial identification and other aspects.
A sensitive, stable and reusable piezoelectric biochip was developed by using microelectronic technology to fabricate micro-piezoelectric sensor array and molecular self-assembly technology to chemically bond biomolecular probes, and real-time dynamic monitoring of the reaction process between probes and target molecules on biochips was realized.
Through the clinical application of hepatitis B, tuberculosis bacteria gene detection, environmental hormone detection and Chinese medicine fingerprint recognition, it is proved that it has the advantages of accuracy, sensitivity, high efficiency, fast, simple equipment and low cost, and has broad application prospects in medicine and health, environmental protection and military reconnaissance.